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Canadian Journal of Anesthesia, Vol 10, 53-56, Copyright © 1963 by Canadian Anesthesiologists' Society

Effect of Epinephrine on the Human Heart during Methoxyflurane Anaesthesia

ANDRÉ JACQUES M.D., F.R.C.P.(C)1 and FERNANDO HUDON M.D., F.R.C.P.(C)1

1 Department of Anaesthesia, L'Hôtel-Dieu de Québec, Quebec 4

This report is an analysis of 150 cases of N2O–O2–methoxyflurane inhalational anaesthesia with the concomitant topical and subcutaneous use of epinephrine added either to cocaine, hexylcaine, or lidocaine to overcome oozing in the surgical field. During the course of anaesthesia, the pulse, the blood pressure, and the cardiac rhythm were monitored with appropriate apparatus, and ventilation was adequately maintained with Bird ventilators No. 4 and No. 8.

The effects on the human heart and the circulation were transient, which might demonstrate that (1) methoxyflurane does not enhance the side-effects of epinephrine on the human heart and (2) that adequate ventilation of the lungs is a safe barrier to many anaesthetic complications.






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Copyright © 1963 by the Canadian Anesthesiologists' Society.