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Canadian Journal of Anesthesia, Vol 10, 57-65, Copyright © 1963 by Canadian Anesthesiologists' Society

Thiethylperazine: A Clinical Investigation of a New Anti-emetic Drug

CYRIL TAYLOR M.D.1 and VERGIL K. STOELTING M.D.1

1 Department of Anesthesiology, Indiana University School of Medicine, Indianapolis, Indiana

A new phenothiazine compound, thiethylperazine malate, was investigated with regard to its effectiveness in preventing postoperative emesis and to its sideeffects. A double-blind technique was employed. Thiethylperazine or a placebo was injected intramuscularly at the termination of anaesthesia, and the patient was observed in the recovery room for two hours. There was a significant reduction in the incidence of postoperative emesis in patients who had received 5.0 mg. or 10.0 mg. of thiethylperazine. There was a slight prolongation of postanaesthetic somnolence by the drug. Hypotension, greater than 30 mm. Hg, was more frequent in the group of patients who had received 10.0 mg. of thiethylperazine. No other side-effects were detected. Thiethylperazine appeared to be a very useful anti-emetic, and is a forward step in the drive to find one with maximal efficiency and minimal side-effects.






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Copyright © 1963 by the Canadian Anesthesiologists' Society.