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Canadian Journal of Anesthesia, Vol 10, 264-275, Copyright © 1963 by Canadian Anesthesiologists' Society

Methoxyflurane: Effects Upon Cardiac Contractility, Rhythmicity, and Blood Pressure in Dogs

ROGER BRASSARD M.D.1, CLAYTON A. JOHNSON B.S.1, JOSEPH J. BUCKLEY M.D.1, and JAMES H. MATTHEWS M.D.1

1 Department of Anesthesiology, University of Minnesota Medical Center, Minneapolis 14, Minnesota

Methoxyflurane was administered to unpremedicated dogs in increasing and decreasing concentrations while normal pulmonary ventilation was rigidly maintained. Myocardial contractility, blood pressure, pulse rate, electrocardiogram, and electroencephalogram were recorded continuously.

A progressive decrease in contractile force of the heart muscle resulted as the inhaled concentration of methoxyflurane increased. A parallel decrease in systolic, diastolic, and pulse pressure occurred. Sinus bradycardia and an alteration in repolarization of cardiac muscle accompanied the dynamic changes. A lag occurred in recovery of all cardiovascular functions and the EEG following withdrawal of the agent. Burst suppression appeared when hypotension below 90 mm. Hg occurred.

A comparison of the results of this study with those previously reported is presented.

Note:

Medical Student Research Assistant, supported by Public Health Service Medical Student Training Grant No. 2R-24 (C3), from the Division of General Medical Sciences, Public Health Service.






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Copyright © 1963 by the Canadian Anesthesiologists' Society.