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Canadian Journal of Anesthesia, Vol 10, 508-515, Copyright © 1963 by Canadian Anesthesiologists' Society

Some Effects of Succinylcholine Chloride in Conscious Human Subjects

S. L. VANDEWATER M.D., F.R.C.P.(C)1, S. G. LAVERTY M.B., CH.B.1, DUGAL CAMPBELL PH.D.1, and R. E. SANDERSON PH.D.1

1 Departments of Anaesthesia, Psychiatry, and Psychology, Queen's University, Kingston, Ontario

Succinylcholine (20 mg.) was administered to alcoholic patients as part of a conditioned aversion therapy against alcohol. No anaesthesia was used. The effects of succinylcholine on respiration, heart rate, skin resistance, and muscle tension were recorded. A marked bradycardia was consistently observed during the period of apnoea.

In three subjects these observations were repeated combining the injection of thiopentone (0.4 gm.) with succinylcholine (20 mg.). No bradycardia appeared and the period of apnoea was shorter than when the succinylcholine was given alone.






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Copyright © 1963 by the Canadian Anesthesiologists' Society.