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Canadian Journal of Anesthesia, Vol 11, 1-6, Copyright © 1964 by Canadian Anesthesiologists' Society

The Response of the Newborn Infant to Muscle Relaxants

H C CHURCHILL-DAVIDSON MA, MD, FFARCS1 and R P WISE MB, BS, FFARCS1

1 Department of Anaesthetics, St Thomas's Hospital, London, S E 1, England

1 The injection of a non-depolarizing relaxant drug (d-tubocurarine) in the neonate leads to a neuromuscular block similar to that observed in an adult patient

2 There was no evidence of increased sensitivity of the hand muscles of the neonate to d-tubocurarine as compared with the adult The possibility of increased ‘sensitivity’ of the respiratory muscles is discussed

3 The similarity between some aspects of neuromuscular transmission in the newborn and in patients with myasthenia gravis is described

4 The suggestion is made that d-tubocuranne (well diluted) is more suitable than suxamethonium for producing muscular lelaxation in the neonate






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Copyright © 1964 by the Canadian Anesthesiologists' Society.