CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DOBKIN, A. B
Right arrow Articles by BYLES, P. H
Right arrow Search for Related Content
PubMed
Right arrow Articles by DOBKIN, A. B
Right arrow Articles by BYLES, P. H

Canadian Journal of Anesthesia, Vol 11, 41-71, Copyright © 1964 by Canadian Anesthesiologists' Society

Innovan-N2O Anaesthesia in Normal Men Effect on Respiration, Circulatory Dynamics, Liver Function, Metabolic Functions, Acid-Base Balance, and Psychic Responses

ALLEN B DOBKIN MD1, JACOB S ISRAEL MD1, and PETER H BYLES MB1

1 Department of Anesthesiology, State University of New York, Upstate Medical Center, and University Hospital, Syracuse, New York

The experimental evaluation of intravenous Innovan anaesthesia in healthy male subjects showed that this drug mature, in a low dose, exerts a marked neuro and hypno sedative effect and, in higher doses, with N2O–O2 supplementation, produces unconsciousness accompanied by depression of the sympathetic nervous system, as shown by the Horner's syndrome, warm, dry extremities, engorged veins, and moderate depression of blood pressure Cardiovascular depression appears to be minimal and of short duration and, in most of the subjects, the cardiovascular system remained remarkably stable during the action of this agent Respiratory depression is intense for a short period and mild for a much longer period Hypertonic reactions, affecting the neuromuscular system, appear early as spasm of the thoracic, abdominal, and neck muscles, which would probably necessitate the use of muscle relaxants to ensure adequate pulmonary ventilation, and later as restlessness and dyskinesia of the muscles in the face and neck–which may require treatment with anticholinergic drugs such as atropme or cogentin. Two subjects complained of the occurrence of hallucinations which lasted several days in one case Whether or not this disturbance was due to Innovan alone could not be established Representative liver function and metabolic tests indicate that Innovan is a relatively non-toxic substance in the dose range required for approximately one hour of general anaesthesia. The incidence of nausea and vomiting appears to be negligible after this anaesthetic

On the basis of these experiments, it is difficult to say whether general anaesthesia with Innovan-N2O has many great advantages over the use of thiopental, cyclopropane, halothane, methoxyflurane, or trichlorethylene and their combinations with nitrous oxide, but it appears worthy of extensive trial






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1964 by the Canadian Anesthesiologists' Society.