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Canadian Journal of Anesthesia, Vol 11, 614-620, Copyright © 1964 by Canadian Anesthesiologists' Society

The Influence of Epidural Anaesthesia on Cardiac Excitability in Profound Hypothermia

A GALINDO MD1 and J H SPROUSE MD2

1 Section on Neuroanesthesiology, Surgical Neurology, National Institute of Neurological Diseases and Blindness, National Institutes of Health; Present address McGill University, Montreal Neurological Institute, Montreal, Canada
2 Anesthesiology Department, Clinical Center, National Institutes of Health; Present address University of Kentucky, Department of Anesthesiology, Lexington, Ky

The effect of total sympathetic block by epidural anaesthesu was studied during profound hypothermia It protected against the incidence of ventricular fibrillation over 20° C This protection seemed to be mediated through a steady equilibrium of the heart rate, duration of QRS, and the length of refractoriness (TRP) The ventricular fibrillatory threshold became lower and equal to the ventricular diastohc threshold in the animals that fibrillated This threshold (VDT) had wide changes in the control group and decreased sharply below 25° C m the experiments in which ventricular fibrillation occurred at higher temperatures However, ventricular diastolic threshold alone does not explain the protection obtained from sympathetic block protected against reflex factors in induced ventricular fibrillation. Total epidural anaesthesia during hypothermia produced marked arterial hypotension






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Copyright © 1964 by the Canadian Anesthesiologists' Society.