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Canadian Journal of Anesthesia, Vol 12, 34-38, Copyright © 1965 by Canadian Anesthesiologists' Society

Neuroleptanalgesics: 1. Effect of Droperidol, Fentanyl, Innovar, Benzquinamide, and Pentazocine on the Duration of Thiopental-Induced Sleep in Dogs

ALLEN B. DOBKIN M.D.1 and PETER K. Y. LEE M.D.1

1 Department of Anesthesiology, State University of New York, Upstate Medical Center, Syracuse 13210, New York

A standardized crossover experiment was employed to determine the effect of combining some new neuroleptic and analgesic drugs with thiopental on the duration of thiopental-induced sleep in dogs. The dose selected for each of the drugs was within the therapeutic effective dose range of their primary action, and was unlikely to produce severe cardilorespiratory depression. Droperidol prolonged thiopental-indueed sleep and delayed full recovery by more than twice the time for thiopental alone. Fentanyl and pentazocine had approximately the same effect, causing a 50 per cent to 75 per cent delay in recovery. The effect with Innovar was less than that of droperidol, but was unuch more than that with fentanyl, indicating a dominant action of droperidol in the mixture with respect to the hypnotic effect. Benzquinamide had virtually np effect on the duration of thiopental-induced sleep.

A few side-effects of significance were observed: droperidol and Innovar commonly caused diarrhoea the day after the test, and fentanyl caused a brief period of apnoea during the test in a few dogs.

From these experiments, we concluded that if Innovar is used for anaesthesia with thiopental, no more should be given after anaesthesia is fully induced, and maintenance requirements should be restricted to supplementary doses of either fentanyl (for analgesia) or thiopental (for hypnosis). When fentanyl is used, one should always be prepared to augment pulmonary ventilation because apnoea is likely to occur shortly after its injection. Benzquinamide has no hypnotic or analgesic properties which would warrant its use during anaesthesia, whereas pentazocine appears quite useful in both these respects and has no apparent side-effects.

Note:

Department of Anesthesiology, State University of New York, Upstate Medical Center, Syracuse 13210, New York.






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Copyright © 1965 by the Canadian Anesthesiologists' Society.