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Canadian Journal of Anesthesia, Vol 12, 90-98, Copyright © 1965 by Canadian Anesthesiologists' Society

Determination of Blood Halothane Levels by Gas Chromatography

RICHARD H. GADSDEN PH.D.1, K. BENJAMIN H. RISINGER B.S.1, and ERVIN E. BAGWELL PH.D.1

1 Departments of Chemistry and of Pharmacology, Medical College of South Carolina, Charleston, South Carolina

A method of isolation by distillation of halothane from blood and its subsequent chromatographic detection and quantitation have been described. The method is simple, rapid, and inexpensive. It lends itself well to incorporation into anaesthetic investigations when blood (and tissue) anaesthetic levels must be obtained in serial manner.

The accuracy of the method, based on tests of reproducibility and recovery, is within ±5 per cent. These data are not of a selected nature and represent a testing of the isolation and chromatographic techniques for quantitative analytical adequacy.

Some data obtained from animal experiments are presented. Detailed correlation of these data with cardiovascular and acid-base investigations will appear elsewhere.13






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Copyright © 1965 by the Canadian Anesthesiologists' Society.