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Canadian Journal of Anesthesia, Vol 12, 129-136, Copyright © 1965 by Canadian Anesthesiologists' Society

Amitriptyline (Elavil) A Sedating Antidepressant with Pressor Activity for Preoperative Medication

PAUL R LEVESQUE MD1, OGDEN R LINDSLEY PHD1, and BENJAMIN E ETSTEN MD1

1 Department of Anesthesiology, Tufts University School of Medicine and Pratt Clinic—New England Center Hospital, and the Behavior Research Laboratory of Harvard Medical School, Boston, Mass

Amitriptyline (Elavil) was evaluated as a premedicant sedative and its effect upon recovery time following halothane anaesthesia was objectively quantitated in man by means of the Free-Operant Behaviour Technique. Amitriptyline exerted a specific degree of sedation without prolonging recovery time following halothane anaesthesia. Following the intravenous administration of amitriptyline, the arterial blood pressure either was slightly elevated or was maintained at the resting levels.

Note:

This work was supported in part by grants from the National Institutes of Mental Health (M-3167), United States Public Health Service and from Merck, Sharp and Dohme Research Laboratories






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Copyright © 1965 by the Canadian Anesthesiologists' Society.