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Canadian Journal of Anesthesia, Vol 12, 367-378, Copyright © 1965 by Canadian Anesthesiologists' Society

Metabolic Changes Induced in the Limb during Tourniquet Ischaemia

R DÉRY MD FRCP(C)1, J PELLETIER MD1, A JACQUES CD,MD,FRCP(C)1, M CLAVET MD1, and J J HOUDE MD1

1 Department of Anaesthesia and Resuscitation, Hôtel Dieu of Québec, Québec, P Q

The metabolic changes induced by tourniquet ischaemia in a limb are suggested as important factors in the pathogenesis of tourniquet paralysis After 30 minutes of circulatory arrest, when nerve conduction and excitability have been found to disappear, the incidental disorders in peripheral venous blood were anoxia, hypercapnia, mixed respiratosy and metabolic acidosis, hypoglycaemia, hyper–kalaemia,lowered ionized calcium, along with slightly increased total calcium and proteins, and increased lactic acid concentrations and, by contrast, a decrease in pyravic acid levels Further research is necessary in order to define accurately the specific factor among these that is responsible for nerve damage and paralysis

Note:
Presented at the Annual Meeting, the Roval College of Physicians and Surgeons of Canada, January 21–23, 1965






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Copyright © 1965 by the Canadian Anesthesiologists' Society.