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Canadian Journal of Anesthesia, Vol 12, 379-385, Copyright © 1965 by Canadian Anesthesiologists' Society

Sodium Gamma Hydroxybutyrate Laboratory and Clinical Studies

LAWRENCE O LUND MD1, JESSE H HUMPHRIES MD1, and ROBERT W VIRTUE MD,PHD1

1 Division of Anesthesiology University of Colorado Medical Center, Denver, Colorado

Sodium gamma hydroxybutyrate has been administered intravenously to dogs to determine the anaesthetizing dose, the toxic dose, the lethal dose, and the "anaesthetic index" Unpremedicated aninials exhibited severe paiiasympathomimetic activity Premedication with pentobarbital offset the undesirable effects of the drug, and raised the AI quite significantly Large doses of the butyrate were necessary for production of analgesia in rats The drug has been administered to 30 surgical patients Its use was chara– terized by maintenance of blood pressure and spontaneous respiration The subjects slept 2 to 3 hours Occasional periodic respiration was observed in the recovery room

Note:
Supported in part by a grant from the Wyeth Company






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Copyright © 1965 by the Canadian Anesthesiologists' Society.