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Canadian Journal of Anesthesia, Vol 12, 634-640, Copyright © 1965 by Canadian Anesthesiologists' Society

Effects of Phenylephrine during Halothane Anaesthesia in Man

J.W. R. McINTYRE F.F.A.R.C.S.1

1 Department of Anaesthesia, University of Alberta Hospital, Edmonton, Alberta

Phenylephrine in varying dosage was administered to patients during surgery under anaesthesia with nitrous oxide:halothane and relaxant, when the systolic blood pressure had fallen to 48 to 80 per cent of the preoperative value. Isolated ventricular extrasystoles occurred in two of fifty cases, and a varying degree of bradycardia was demonstrated. A case report is presented in which the intravenous injection of atropine to correct a reflex bradycardia resulted in an atrioventricular rhythm, and attention is drawn to the effects of such changes on the cardiac output. Phenylephrine may not have a place in the treatment of hypotension during general anaesthesia, but it is concluded that if the drug is to be administered to a patient weighing approximately 150 pounds (70 kg.) anaesthetized with halothane, increments of 0.1–0.2 mg. should be used.






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Copyright © 1965 by the Canadian Anesthesiologists' Society.