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Canadian Journal of Anesthesia, Vol 13, 119-123, Copyright © 1966 by Canadian Anesthesiologists' Society

Cardiovascular Reactions to Gamma Hydroxybutyrate in Man

ROBERT W. VIRTUE M.D.1, LAWRENCE O. LUND M.D.1, HENRY J. BECKWITT M.D.1, and JOHN H. K. VOGEL M.D.1

1 Division of Anesthesiology and Cardiovascular Pulmonary Laboratory, University of Colorado Medical Center, Denver, Colorado

Eight volunteer subjects were put to sleep with 65 mg./kg. of gamma hydroxybutyrate. Respiratory function and cardiac output were determined. Cardiac output diminished, related to a reduction of either cardiac rate or stroke volume or both, and increased again to control levels on administration of atropine. Spontaneous respiration was well maintained. Once the subject had recovered, he rapidly became alert without residual depression.

Several serum enzyme activities, blood glucose, and blood urea nitrogen values remained at control levels throughout the anaesthetic period.

Note:

Supported by a grant from the Wyeth Company.

Dr. Beckwitt and Dr. Vogel received support from the American Heart Association and the Idaho Heart Association respectively.






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Copyright © 1966 by the Canadian Anesthesiologists' Society.