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Canadian Journal of Anesthesia, Vol 13, 98-108, Copyright © 1966 by Canadian Anesthesiologists' Society

The Oxygen Tightrope

H. BARRIE FAIRLEY M.B., B.S., F.F.A.R.C.S.1

1 Department of Anaesthesia, University of Toronto

During anaesthesia and during the management of respiratory failure by intermittent positive pressure ventilation, incipient hypoxaemia is common owing to the frequent occurrence of an increased physiological shunt. This hypoxaemia may be offset by raising the inspired oxygen tension and by hyperventilation. The former may produce alveolar collapse over short periods, and pulmonary oxygen toxicity if sustained. The latter can be shown to exaggerate hypoxaemia under certain circumstances.

The thesis is propounded that there is an upper and lower safe limit for the inspired oxygen tension, that these limits may be partially dependent upon carbon-dioxide levels, and that they may differ in patients with chronic pulmonary disease.

Note:

Based upon a guest lecture given at the Annual Meeting of the Australian Society of Anaesthetists, Adelaide, September, 1965. The investigations reported have been supported by grant # MBA 1213 from the Medical Research Council of Canada.






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Copyright © 1966 by the Canadian Anesthesiologists' Society.