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Canadian Journal of Anesthesia, Vol 13, 282-289, Copyright © 1966 by Canadian Anesthesiologists' Society

Effects of Halothane on Life Expectancy of Mice

ANTONIO BOBA M.D.1 and JAMES DREWS M.D.1

1 Department of Anesthesiology, Albany Medical Center Hospital, and the Albany Medical College of Union University, Albany, New York

An investigation of the effects of repeated halothane administration to mice during the early period of their adult life has shown that at high concentrations the drug is immediately lethal to a significant number, and that at very low concentrations it has no significant immediate lethal effects. In the intermediate concentration range the drug has a moderate lethal effect which does not disappear with cessation of administration of the drug but continues to exert its effects for an additional three- to six-week period.

Once an animal has reached the expected median of life, as determined in the control group, its life expectancy is not affected any longer by previous exposure to halothane in any concentration.

Some considerations about the assessment and evaluation of the toxicity of certain drugs, implicit in these results, have been discussed.

Note:

Supported, in part, by a grant from Winthrop Research Institute.






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Copyright © 1966 by the Canadian Anesthesiologists' Society.