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Canadian Journal of Anesthesia, Vol 13, 361-367, Copyright © 1966 by Canadian Anesthesiologists' Society

Effect of Nitrous Oxide on Myocardial Contractility of Dogs

RICHARD O. LUNDBORG M.D., JAMES H. MILDE , and RICHARD A. THEYE M.D.

The effect of nitrous oxide on myocardial contractility and haemodynamics has been studied in unpremedicated, closed chest, anaesthetized dogs (1% halothane). Substitution of N2O (75%) for the N2 (75%) in the inspired mixture (O2, 25%) was associated with minor or insignificant changes in cardiac output, arterial blood pressure, oxygen uptake, and blood O2 or CO2 levels. Myocardial contractility, however, was reduced by the presence of N2O, and both stroke work and peak dP/dT were decreased in the presence of concurrent increased end-diastolic ventricular pressures. In the clinical use of N2O, the advantages of potent, reversible analgesia must be considered along with the potential disadvantages of reduced myocardial contractility and, ordinarily, lower levels of arterial O2.

Note:

Mayo Clinic and Mayo Foundation, Section of Anesthesiology. Read at the meeting of the Canadian Anaesthetists' Society, Banff, Alberta, Canada, June 6 to 10, 1966. This investigation was supported in part by Research Grant H-4881 from the National Heart Institute, Public Health Service.

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Copyright © 1966 by the Canadian Anesthesiologists' Society.