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Canadian Journal of Anesthesia, Vol 13, 374-377, Copyright © 1966 by Canadian Anesthesiologists' Society

The Effect of Diazepam on the Respiratory Response to Carbon Dioxide

STEPHEN N. STEEN SC. D., M.D.1, STANLEY W. WEITZNER M.D.1, KEISUKE AMAHA M.D.1, and LEONARDO R. MARTINEZ M.D.1

1 Department of Anesthesiology, State University of New York Downstate Medical Center and Kings County Hospital Center, Brooklyn, New York, U.S.A.

Six healthy adult female volunteers were used in the quantitative assessment of their respiratory responses following intravenous administration of meperidine and diazepam. A modified rebreathing CO2-challenge technique of Eckenhoff et al.,5 previously reported,6 was used for this purpose.

The CO2 stimulus response curves obtained confirmed the respiratory depressant response following the use of 0.5 mg./kg. meperidine. Diazepam, at dose levels up to 0.066 mg./kg., produced no statistically significant respiratory response to carbon dioxide detectable by this method (p < 0.025).

Note:

Presented in part at the 159th Annual Convention of the Medical Society of New York, Section on Anesthesia, New York City, February 15, 1965.

Recipient of U.S.P.H.S. Research Career Development Award NB-K-17652.

Present address: Karolinska Hospital, Thoracic Clinic, Stockholm, Sweden.






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Copyright © 1966 by the Canadian Anesthesiologists' Society.