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Canadian Journal of Anesthesia, Vol 13, 378-389, Copyright © 1966 by Canadian Anesthesiologists' Society

Blood Levels and Cardiovascular Dynamics During Fluroxene Anaesthesia in Dogs

E. E. BAGWELL PH.D.1, R. H. GADSDEN PH.D.1, K.B. H. RISINGER M.S.1, and E. F. WOODS PH.D1

1 Departments of Pharmacology, Anesthesiology, and Chemistry, Medical College of South Carolina, Charleston, South Carolina

A gas chromatographic technique has been described which allows the quantitative measurement of blood and vapour concentrations of trifluoroethylvinyl ether (fluroxene). Using this method, arterial and venous blood levels of fluroxene were measured during increasing inspired concentrations of the agent, and correlated with concurrent changes in circulatory dynamics.

During light levels of anaesthesia (6.0 per cent) arterial and venous concentrations of fluroxene were 32 and 26 mg./100 ml. respectively. At this time there was minimal depression of the cardiovascular system. When the inspired concentration was increased there was progressive depression of aortic pressure, ventricular contractile force, aortic flow, and calculated stroke volume. Heart rate was not significantly altered until deep levels of anaesthesia were obtained. Calculated peripheral resistance was not significantly altered, and it is felt that this, along with the depression of contractile force, indicates that myocardial depression plays a primary role in the over-all circulatory depression occurring during deep levels of fluroxene anaesthesia.

In the animals in which anaesthesia was induced with thiopental and maintained with fluroxene for two hours, there was only minimal depression of the cardiovascular system. Most of the observed depression occurred during the thiopental induction, and maintenance with fluroxene failed to produce any further depression.

Note:

This work was supported by grants from the South Carolina Heart Association, National Heart Institute (Grants No. NB-03632 and HE-05348), and Ohio Chemical Company. A preliminary report of these findings was presented at the annual meeting of the Federation of American Societies for Experimental Biology in April, 1964.






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Copyright © 1966 by the Canadian Anesthesiologists' Society.