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Canadian Journal of Anesthesia, Vol 13, 611-615, Copyright © 1966 by Canadian Anesthesiologists' Society

Further Studies of Three Anti-emetics in Common Use

RICHARD G. B. TAN DRS. MED. (AIRLANGGA)1, LARRY J. GELMON 1, and GORDON M. WYANT F.F.A.R.C.S., F.R.C.P.(C)1

1 Department of Anaesthesia, University of Saskatchewan, and University Hospital, Saskatoon, Saskatchewan

This study was undertaken in an attempt to resolve the contradictions between our previous findings in dogs regarding the anti-emetic properties of trimethoxybenzamide and the findings of Purkis regarding its properties in man.

From these further investigations it is clear that a reversal effect does not occur when large doses of trimethoxybenzamide are administered. The discrepancies are rather due to the fact that the therapeutic effect of trimethoxybenzamide is very short, whereas the effect of thiethylperazine and perphenazine is much more prolonged.

The difference between our original results and Purkis's can now be explained on the basis of the more prolonged observation of patients carried out by Purkis, as opposed to our acute experiments in dogs, when only the presence or absence of protection to a single stimulus was recorded.

Note:

Dr. Tan was a Research Fellow and Mr. Gelmon a summer student in the Department of Anaesthesia and as such carried out work on Parts A and B respectively






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Copyright © 1966 by the Canadian Anesthesiologists' Society.