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Canadian Journal of Anesthesia, Vol 14, 79-86, Copyright © 1967 by Canadian Anesthesiologists' Society

Ventricular Arrhythmias Induced by Aminophylline During Halothane Anaesthesia in Dogs

MASUHIKO TAKAORI M.D., PH.D.1 and ROBERT W. LOEHNING M.D., PH.D.1

1 Division of Anesthesiology, College of Medicine, University of Utah, Salt Lake City, Utah

Intravenous administration of aminophylline to dogs anaesthetized with 1 per cent halothane resulted in ventricular arrhythmias in 12 of 16 animals (ventricular fibrillation in three animals). Halothane-aminophylline arrhythmias disappeared when the animals were ventilated with 3 per cent halothane but reappeared when the animals were subsequently ventilated with room air. Arrhythmias did not occur when aminophylline was given to animals ventilated with 3 per cent halothane or to dogs anaesthetized with pentobarbital. Following administration of aminophylline one out of ten unanaesthetized dogs and two of six animals ventilated with 3 per cent ether developed short periods of multifocal premature ventricular contractions. A possible explanation of the data obtained is presented.

Note:

Dr. Takaori's present address is Department of Anesthesiology, University of Osaka, School of Medicine, Osaka, Japan






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Copyright © 1967 by the Canadian Anesthesiologists' Society.