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Canadian Journal of Anesthesia, Vol 14, 87-93, Copyright © 1967 by Canadian Anesthesiologists' Society

The Effect of Hyperventilation on Arterial Oxygen Tension: A Theoretical Analysis

H. B. FAIRLEY M.B., B.S., F.F.A.R.C.S.1

1 Department of Anaesthesia, University of Toronto

The clinical finding that acute hyperventilation by intermittent positive pressure may produce a progressive reduction in Pa O2 has stimulated a theoretical analysis of the factors involved. When Pa O2 is below approximately 75 mm. Hg at Pa CO2 40 mm. Hg, hyperventilation will produce a reduction in Pa O2. This will be offset if, coincidently, physiological shunt is reduced or cardiac output is increased. The effect will be exaggerated if cardiac output is impaired or physiological shunt is increased.

The level of the inspired oxygen tension is of relatively less significance, as is the haemoglobin level, provided this remains stable.

Note:

Based on a paper read at the annual meeting of the Canadian Anaesthetists' Society, June 1966.






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Copyright © 1967 by the Canadian Anesthesiologists' Society.