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Canadian Journal of Anesthesia, Vol 14, 424-434, Copyright © 1967 by Canadian Anesthesiologists' Society

Ventilation and Blood Gases in Anaesthetized Patients

MARTIN I. GOLD M.D.1 and MARTIN HELRICH M.D.1

1 Department of Anesthesiology, University of Maryland School of Medicine and Hospital, Baltimore, Maryland

Blood gases, tidal volumes, and respiratory rates were measured preoperatively and during surgery with intermittent positive pressure breathing of 50 per cent oxygen. The ventilator was set to provide a tidal volume and rate closely approximating that in the awake state.

Paoo2 dropped significantly during IPPB despite the similar Pioo2, Vt, f, and V·E. Pacoco2 remained the same. As time elapsed, a progressive fall in Paoo2 occurred. The Paoo2 reached its minimum at approximately one hour after the initiation of IPPB. Individual patient responses varied considerably for both changes in Paoo2 and Pacoco2. Although three patients developed Paoo2 values below 100 mm. Hg, none was considered hypoxaemic since the respective Paoo2 was at a level above the air control. Some Paoo2 values dropped approximately 150 mm. Hg below the awake control while others remained at the 250 mm. Hg level. It should be realized that the tidal volumes used were lower than that during the usual clinical administration of anaesthesia. Changes in Pacoco2 were pot usually related to changes in Paoo2, and hypocarbia and acceptable estimated V·A were frequently associated with a Paoo2 lower than during the control. Therefore, under the same conditions, it is concluded that if the tidal volume and respiratory rate used during IPPB are identical to those of the awake control, then during the inhalation of 50 per cent O2 patients are able to maintain normal Pacoco2 and slightly lower Paoo2

Note:

This investigation was supported by Public Health Service Research Grant HE-06429 from the National Institutes of Health.






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Copyright © 1967 by the Canadian Anesthesiologists' Society.