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Canadian Journal of Anesthesia, Vol 14, 551-566, Copyright © 1967 by Canadian Anesthesiologists' Society

Relationship of Metabolic Acidosis and Capillary Pco2 in Cyclopropane and Halothane Anaesthesia

GORDON F. CLARK M.D.1

1 Lion's Gate Hospital, 230 East 13th Street, North Vancouver, B.C

Acid-base studies were done on 85 healthy subjects undergoing elective surgery during anaesthesia with cyclopropane and halothane. All patients were subjected to artificial respiration with a mechanical assistor-breather, and respiratory minute volume was adjusted to produce a group with elevated Pco2 and a group with depressed Pco2 for each anaesthetic agent. Half-hourly acid-base observations showed metabolic acidosis to develop in both cyclopropane and halothane anaesthesia irrespective of the level of Pco2 and to be progressive with time. The extent of metabolic acidosis with cyclopropane is not statistically different from that with halothane. The possible causes for metabolic acidosis in anaesthesia with these two agents are briefly discussed.

Note:
This study was assisted by funds provided by the Department of National Health and Welfare, Health Branch, Grant 609-7-141.






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Copyright © 1967 by the Canadian Anesthesiologists' Society.