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Canadian Journal of Anesthesia, Vol 15, 244-257, Copyright © 1968 by Canadian Anesthesiologists' Society

Influence of Anaesthetics On Rheology of Human Blood

H. BEN-ZION ARONSON F.F.A.R.C.S.L1, PAUL R. LEVESQUE M.D., STANLEY CHARM M.S., SC.D., and BENJAMIN ETSTEN M.D.

1 Research Fellow in Anesthesiology, New England Medical Center Hospitals, Boston, Mass., and Lecturer in Anesthetics at Hadassah Hebrew University, Jerusalem, Israel

Cyclopropane, halothane, and methoxyflurane were investigated for their effects on the viscometry of freshly drawn human blood (group O, Rh+). A total of 43 blood and 63 plasma samples containing specific anaesthetic agents were studied under controlled conditions of temperature, pH, Pco2, Po2, and red blood cell and plasma protein concentrations. A series of three cone plate viscometers, each with different shear rate ranges from 1500 to 6.75 sec.-1, was used. The Casson viscosity of blood and apparent plasma viscosity were determined from the slope of the shear stress-shear rate relationship plotted on a square root scale. Yield stress was determined by extrapolation from the shear stress axis intercept. Our findings indicate that the three anaesthetic agents, within concentrations equivalent to those used during clinical anaesthesia, caused no discernible effect on either yield stress or the apparent viscosity of blood or plasma. However, there was a marginal increase of the yield stress of blood with high concentrations of cyclopropane (above 20 mg.%) and a trend toward reduced plasma viscosity in all of the methoxyflurane samples.

Note:

Department of Anesthesiology, Tufts University School of Medicine and New England Medical Center Hospitals, and Department of Physiology, Tufts University School of Medicine. This work was supported by grants HE 01711 and HE 08783 from the National Institutes of Health, U.S. Public Health Service.






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Copyright © 1968 by the Canadian Anesthesiologists' Society.