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Canadian Journal of Anesthesia, Vol 15, 258-266, Copyright © 1968 by Canadian Anesthesiologists' Society

Effects of Halothane Anaesthesia and Surgery on Adrenocortical Function in Man

TSUTOMU OYAMA M.D.1, S. SHIBATA M.D.1, F. MATUSMOTO M.D.1, M. TAKIGUCHI M.D.1, and T. KUDO B.S.1

1 Department of Anaesthesia, Hirosaki University School of Medicine, Hirosaki, Japan

The present study was undertaken to investigate whether or not preanaesthetic medication and halothane anaesthesia affect adrenal cortical function in man as judged by their influence on the plasma levels of free 17-hydroxycorticosteroids. The blood samples were taken in the morning between 8:15 and 8.45 a.m. before induction of anaesthesia, during anaesthesia alone, during surgery, and in the recovery room. The determination of free 17-OHCS in plasma was made by Peterson's modification of the Porter-Silber method. Twenty patients were given halothane anaesthesia and another eleven patients received premedication alone without anaesthesia.

The mean plasma level of 17-OHCS in the preanaesthetic period was in the range of 10.0-10.8 µg. per 100 ml., which was significantly lower than for the non-premedicated patients. Although halothane anaesthesia for 15 minutes after induction with thiopental evoked slight but insignificant increase of 17-OHCS level, halothane anaesthesia for 30 minutes without employing thiopental significantly increased the plasma 17-OHCS levels above the preinduction levels, from 10.8 ± 1.4 to 17.5 ± 1.6 µg. (± = standard error) per 100 ml. The surgical stress increased plasma 17-OHCS levels markedly. These findings indicate that halothane anaesthesia has a stimulating effect on adrenal cortical function in man.






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Copyright © 1968 by the Canadian Anesthesiologists' Society.