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Canadian Journal of Anesthesia, Vol 15, 267-275, Copyright © 1968 by Canadian Anesthesiologists' Society

Anaesthetic and Surgical Considerations in Partial Hepatectomy

JOHN I. DAVIES M.D., F.R.C.P.(C)1 and ABRAHAM KAPLAN M.D.1

1 Department of Surgery, Veterans Administration Hospital, Kansas City, Missouri, and Departments of Anesthesia and Surgery, University of Kansas School of Medicine

A new technique for reducing bleeding during partial hepatectomy has been investigated in dogs. It consists of producing systemic hypotension using trimethaphan alone, and in combination with vasopressin. Hypotension of 20 minutes and resection of 35 per cent of liver substance produced minimal bleeding and insignificant effects on liver function. Further studies are in progress to determine the effects on liver function of hypotension up to 45 minutes in duration and to learn the significance of liver shunts and sphincter mechanisms. Preliminary results are briefly discussed. The hepatic artery flow is dependent on mean aortic pressure. The clinical usefulness of this technique is discussed.






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Copyright © 1968 by the Canadian Anesthesiologists' Society.