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Canadian Journal of Anesthesia, Vol 15, 291-296, Copyright © 1968 by Canadian Anesthesiologists' Society

Reduction in Plasma Cholinesterase Levels after Prolonged Administration of Echothiophate Iodide Eyedrops

T. E. EILDERTON D.D.S.1, O. FARMATI M.D.2, and E. K. ZSIGMOND M.D.3

1 Oral Surgery, Montefiore Hospital, Pittsburgh, Pennsylvania, and Anesthesia Research Laboratory, Allegheny General Hospital, Pittsburgh
2 Anesthesia Department, Spencer Hospital, Meadville, Pennsylvania; University of Pittsburgh School of Medicine
3 Anesthesia Research Laboratory, Allegheny General Hospital, Pittsburgh

Correspondence and requests for reprints should be sent to Dr. Zsigmond

Plasma cholinesterase activity was determined in 71 patients receiving echothiophate eyedrops. A twofold reduction in plasma cholinesterase activity was found in one-third of the patients and a fourfold reduction in one of every seven patients on echothiophate eyedrops. No correlation was found between the duration of the treatment and the plasma cholinesterase levels found in any of the age groups of patients. Special caution must be exercised with patients on echothiophate iodide eyedxops when succinylcholine or ester-type, hydrolysable local anaesthetics are administered in order to prevent prolonged apnoea and/or toxic reactions.

Note:

From the Anesthesia Research Laboratory and the Department of Anesthesiology, Allegheny General Hospital, and the Department of Anesthesiology, Eye and Ear Hospital, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania.

Dr. Eilderton is Senior Resident in Oral Surgery, Montefiore Hospital, Pittsburgh, Pennsylvania, and Postdoctoral Fellow in the Anesthesia Research Laboratory, Allegheny General Hospital, Pittsburgh. Dr. Farmati is Director of the Anesthesia Department, Spencer Hospital, Meadville, Pennsylvania. He is also Assistant Professor in Anesthesiology and Clinical Research Associate in Pharmacology, University of Pittsburgh School of Medicine. Dr. Zsigmond is Anesthesiologist and Director of the Anesthesia Research Laboratory, Allegheny General Hospital, Pittsburgh.






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Copyright © 1968 by the Canadian Anesthesiologists' Society.