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Canadian Journal of Anesthesia, Vol 15, 362-368, Copyright © 1968 by Canadian Anesthesiologists' Society

Adrenocortical Function Related to Methoxyflurane Anaesthesia and Surgery in Man

T. OYAMA M.D.1, S. SHIBATA M.D.1, F. MATSUMOTO M.D.1, A. MATSUKI M.D.1, K. KIMURA M.D.1, T. TAKAZAWA M.D.1, and T. KUDO B.S.1

1 Department of Anaesthesiology, Hirosaki University School of Medicine, Hirosaki, Aomori-Ken, Japan

The effect of preanaesthetic medication, methoxyflurane anaesthesia, and surgery on free hydrocortisone (= 17-OHCS) concentrations in plasma were studied in eleven patients. The preanaesthetic medication significantly decreased plasma levels of free 17-OHCS, but the changes in concentration were variable after methoxyflurane anaesthesia for 30 minutes. Surgical stress evoked significant elevation of free 17-OHCS levels in plasma. These findings would imply that methoxyflurane anaesthesia is not a stressing agent for the adrenal cortex in man.






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Copyright © 1968 by the Canadian Anesthesiologists' Society.