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Canadian Journal of Anesthesia, Vol 15, 399-400, Copyright © 1968 by Canadian Anesthesiologists' Society
Twenty-seven per cent of the rapid sterilization group showed significant loss of fluid. This contrasted with no loss in the slow sterilization procedure. It appears that the negative pressure used in this method draws fluid from the carbocaine vials. An examination of the sealing mechanism of xylocaine and carbocaine vials revealed a tighter seal with thicker rubber in the xylocaine vial. This sealing withstood the negative pressure of the orthovac sterilization, unlike that of the carbocaine stopper. It is recommended that carbocaine vials be sterilized by a slow autoclaving process without negative pressure.
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