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Canadian Journal of Anesthesia, Vol 15, 423-440, Copyright © 1968 by Canadian Anesthesiologists' Society

The Protective Action of Anaesthetics Against Hypoxia

O. SECHER M.D., D.M.S.1 and B. WILHJELM M.D.2

1 University of Copenhagen, Denmark
2 Anaesthesia Laboratory, Pharmacological Institute, University of Copenhagen

On the basis of experimental examinations it has been possible to show that halothane and cyclopropane of the inhalation anaesthetics have a protective action on the brain against anoxia. A similar but even better effect could be obtained by most intravenous anaesthetics, particularly thiopentone. If thiopentone was combined with 5 per cent carbon dioxide, this effect was doubled.

In obstetrical anaesthesia in 217 caesarean sections a barbiturate was used for induction. This lowered the Apgar score of the children, but probably increased the survival rate.

The conclusion to be drawn from these experimental and clinical studies would be that patients who have a possibility of being exposed to anoxia or are under influence of anoxia should preferably be anaesthetized with intravenous barbiturate anaesthetics and in this way be protected to some degree against the damaging influence of anoxia.






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Copyright © 1968 by the Canadian Anesthesiologists' Society.