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Canadian Journal of Anesthesia, Vol 16, 18-26, Copyright © 1969 by Canadian Anesthesiologists' Society

Haemodynamic Changes during Apnoeic Oxygenation in Dogs: Comparisoncl between the Intact and the Pharmacologically Denervated Heart

STANLEY SUN M.B.B.S., F.F.A.R.C.S.I., D.A.1 and D. C. FINLAYSON M.D., F.R.C.P.(C)2

1 Department of Anaesthesia, University of Toronto, and St. Michael's Hospital
2 Department of Anaesthesia, University of Toronto, and Anaesthetist, St. Michael's Hospital

The haemodynamic changes during 30 minutes of apnoeic oxygenation were studied in six intact dogs (group 1) and in 6 with hearts pharmacologically denervated by intravenous atropine and propranolol (group 2), using pentobarbital and succinylcholine anaesthesia. Progressive bradycardia was observed in both groups, but other parameters differed. In group 1 the mean central venous and intra-arterial pressures rose slightly and the cardiac output also rose. In group 2 the mean central venous pressure rose to abnormally high levels, while the mean intra-arterial pressure fell; the cardiac output was depressed in five dogs, while in the sixth it returned to slightly above the control values after an initial fall. Dogs with a pharmacologically denervated heart withstood 30 minutes of apnoeic oxygenation poorly.

Note:

This study was supported in part by grants received from Ayerst, McKenna, and Harrison, who also supplied the propranolol.






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Copyright © 1969 by the Canadian Anesthesiologists' Society.