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Canadian Journal of Anesthesia, Vol 16, 89-98, Copyright © 1969 by Canadian Anesthesiologists' Society

Hereditary Aspects of Malignant Hyperthermia

B. A. BRITT M.D., DIP.ANAES., F.R.C.P.(C)1, W. G. LOCHER M.D.2, and W. KALOW M.D.3

1 Departments of Anaesthesia and Pharmacology, University of Toronto
2 Department of Anesthesiology, St. Mary's Hospital, Wausau, Wisconsin
3 Department of Pharmacology, University of Toronto

Malignant hyperthermia is a genetically inherited condition in many cases. The pattern of inheritance appears to be that of autosomal dominance with reduced penetrance and variable expressivity. The condition is not manifested in infancy or old age. The possible association with musculo-skeletal disease requires further investigation, although a large family tree did not support previously collected evidence in favour of this association.






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Copyright © 1969 by the Canadian Anesthesiologists' Society.