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Canadian Journal of Anesthesia, Vol 16, 282-291, Copyright © 1969 by Canadian Anesthesiologists' Society

Effect of Meperidine on Adrenocortical Function in Man

TSUTOMU OYAMA M.D.1, M. TAKIGUCHI M.D.1, T. TAKAZAWA M.D.1, and K. KIMURA M.D.1

1 Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki, Aomori-Ken, Japan

The present study was undertaken to evaluate the effect of meperidine alone and of meperidine-supplemented nitrous oxide anaesthesia on adrenocortical function, as judged by their influence on plasma free cortisol levels in 30 patients undergoing operation. In conformity with its relatively insufficient sedative effect, meperidine administered intramuscularly (2 mg/kg) one hour prior to induction of anaesthesia did not inhibit adrenocortical stimulation due to emotional stress. Meperidine-nitrous-oxide anaesthesia alone for 30 minutes did not stimulate adrenocortical activity, but could not block adrenocortical stimulation during surgical intervention and after operation.






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Copyright © 1969 by the Canadian Anesthesiologists' Society.