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Canadian Journal of Anesthesia, Vol 16, 309-315, Copyright © 1969 by Canadian Anesthesiologists' Society

Anaesthesia for Cerebral Angiography: Cardiovascular and Cerebrospinal Fluid Pressure Observations in the Monkey under Pentobarbital-Halothane Anaesthesia

J.W. R. McINTYRE F.F.A.R.C.S.1, J.D. R. MILLER M.B., CH.B., F.R.C.P.(C)1, and B.K. A. WEIR M.D., M.SC, F.R.C.S.(C)1

1 Departments of Anaesthesia, Radiology, and Neurosurgery, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta

Cerebral angiography performed under pentobarbital-halothane anaesthesia on normal Rhesus monkeys and those undergoing experimental subarachnoid haemorrhage afforded an opportunity to study the effects of angiography on cardiac rhythm, systemic blood pressure, and cerebrospinal pressure. Meglumine Iothalamate was the contrast medium employed, and the animals varied considerably in temperature, Pco2, and pH. ecg changes were infrequent and minor. Varying degrees of hypotension occurred, and on a few occasions the diastolic blood pressure following the injection of contrast was similar to the csf pressure. These events and the apparently unpredictable responses to angiography under pentobarbital halothane anaesthesia indicate the necessity for monitoring relevant parameters in subjects with suspected or known increase in cerebrospinal fluid pressure.

Note:

Supported in part by M.R.C. Grant no. 2835






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Copyright © 1969 by the Canadian Anesthesiologists' Society.