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Canadian Journal of Anesthesia, Vol 16, 321-330, Copyright © 1969 by Canadian Anesthesiologists' Society

Effects of Pentobarbital and Meperidine on Canine Cerebral and Total Oxygen Consumption Rates

JOSEPH M. MESSICK JR. M.D.1 and RICHARD A. THEYE M.D.1

1 Mayo Clinic and Mayo Foundation: Section of Anesthesiology, Rochester, Minnesota

The individual effects of two premedicant drugs, pentobarbital and meperidine, on both total-body oxygen consumption (Vo2) and cerebral oxygen consumption (CMRo2) rates were studied in dogs during light halothane anaesthesia. Vo2 was measured by means of a modified closed-circuit spirometry apparatus. CMRo2 was calculated from the difference between arterial and sagittal-sinus oxygen content and from the directly measured cerebral blood flow. Pentobarbital decreased Vo2 by 7 per cent and CMRo2 by 10 per cent. Meperidine had no effect on Vo2, but decreased CMRo2 by 13 per cent. These findings are discussed in relation to previous reports of the effects of preanaesthetic medication on Vo2 in man and current concepts of the relationship between cerebral metabolism and function.

Note:

Presented at the Annual Meeting of the Canadian Anaesthetists' Society, June 16-19, 1969. This investigation was supported in part by Special Research Fellowship 1-F3-GM-37, 307-01 from the National Institute of General Medical Sciences (usa), and by Research Grants HE-4881 and NB-7507 from the National Heart Institute, Public Health Service (usa).






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Copyright © 1969 by the Canadian Anesthesiologists' Society.