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Canadian Journal of Anesthesia, Vol 16, 425-428, Copyright © 1969 by Canadian Anesthesiologists' Society

Hazards of Intra-Arterial Injection of Hydroxyzine

GAROLD ENLOE M.D.1, MARILYN SYLVESTER M.S.1, and LUCIEN E. MORRIS M.D.1

1 Anesthesia Research Laboratory, Providence Hospital, Seattle, Washington

A case of gangrene and amputation of the forearm following presumed intraarterial antecubital injection of hydroxyzine is reported.

Studies were made of rabbits given intra-arterial and/or peri-arterial injections of meperidine, propriomazine, hydroxyzine, or normal saline. Only following the injection of hydroxyzine did severe pathological changes regularly occur. These changes were mitigated by the immediated intra-arterial injection of dexamethasone (Decadron®). Flushing the artery with papaverine or lidocaine, although beneficial, seemed to offer less protection.

Note:

Presented in part at the Anesthesia Section of the Annual Meeting of the Washington State Medical Association, September 13, 1967, Seattle, Washington.






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Copyright © 1969 by the Canadian Anesthesiologists' Society.