CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PIEL, M. T.
Right arrow Articles by JONES, G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by PIEL, M. T.
Right arrow Articles by JONES, G.

Canadian Journal of Anesthesia, Vol 16, 538-546, Copyright © 1969 by Canadian Anesthesiologists' Society

Influence of Enzyme Induction on the Sleeping Time of Rats

MICHAEL T. PIEL M.D.1, J. ANTONIO ALDRETE M.D.1, and GEORGE JONES M.D.1

1 Division of Anesthesiology, University of Colorado Medical Center, and the Veterans Administration Hospital, Denver, Colorado

Hepatic microsomal enzyme systems can be activated by pretreatment with phenobarbital, other barbiturates, ddt, and many other drugs. Contrarily, another compound such as skf 525-a, ethionine, and puromycin can inhibit the same enzymatic mechanisms.

The sleep-time periods of albino rats produced by pentobarbital, thiopental, zoxazolamine, ci-581, diazepam, and gamma-hydroxybutyrate were significantly shortened by previous administration of phenobarbital twice daily for four days. However, the duration of action of the same anaesthetics was significantly prolonged when the animals were "pretreated" by the administration of skf 525-a, an inhibiter of liver microsomal enzymes.

Note:

This study was supported by US Public Health Service grant fr 05357-08 to the University of Colorado Medical Center.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1969 by the Canadian Anesthesiologists' Society.