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Canadian Journal of Anesthesia, Vol 16, 547-556, Copyright © 1969 by Canadian Anesthesiologists' Society

Experimental Observations on Propranolol in Anaesthesia

GERALD B. H. LEWIS M.B., B.S., D.A. (R.C.P. & s.)1

1 Department of Anaesthesia, University of Saskatchewan and University Hospital, Saskatoon, Saskatchewan

Epeniphrine-induced arrhythmias in dogs during anaesthesia with diethyl ether, azeotrope halothane/ether, halothane, and methoxyflurane were treated with intravenous propranolol 0.5 mg. There was no demonstrable difference between dogs so treated and controls. All arrhythmias reverted within 122 seconds, with a mean reversal time of 47 seconds. It is suggested that propranolol may not have had time to exert its effect so soon and that the arrhythmias are self-limiting. A method of prophylaxis utilizing a propranolol-epinephrine solution for infiltration anaesthesia and vasoconstriction is suggested as a preferable alternative to treating epinephrine-induced arrhythmias with propranolol. An arousal effect, associated with hyperpnoea, was observed in propranolol during general anaesthesia.

Note:

Presented as part of the Residents' Programme at the Annual Meeting of the Canadian Anaesthetists' Society, Toronto, June 16-19, 1969.






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Copyright © 1969 by the Canadian Anesthesiologists' Society.