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Canadian Journal of Anesthesia, Vol 17, 12-24, Copyright © 1970 by Canadian Anesthesiologists' Society

Apnee A La Succinyldicholine: Etude D'une Population Canadienne-Française

B. HAZEL M.D.1, D. MONIER M.D.2, L. TREMPE 3, M. BEAUCHEMIN M.D.4, and Y. RONDEAU M.D.4

1 Chargé du laboratoire d'enzymologie, département des laboratoires cliniques, et assistant-professeur de clinique, département de médecine, Hôpital Maisonneuve
2 résident en médicine en stage au laboratoire
3 étudiant en médecine de troisiéme année
4 département d'anesthésie, Hôpital Maisonneuve

The present observation correlates the data of five cases of apnoea following the injection of succinylcholine, as well as data on some of the patients' available siblings and a large sampling of a French-Canadian population. The number of heterozygotes in that population is 15/375 or 4.0 per cent, which is comparable to data published by other investigators.

By using the newest technique of benzoylcholine inhibition by sodium chloride proposed by Whittaker, we find mean values of 58.7 among the AA phenotypes and 41.2 among the AS. These values are interpreted against the theory explaining the s by an allelic absence. However since the number of heterozygotes available to us is rather small, we may be dealing with an artefact.

Note:

Ce travail fut accompli grâce à la subvention MA 3690 du Conseil des recherches médicales du Canada, ainsi qu'à la subvention d'établissement du Ministère de la Santé, Conseil de la recherche médicale du Québec. Les demandes de tiré-à-part doivent être adressées au docteur Hazel, Hôpital Maisonneuve, 5415, boulevard de l'Assomption, Montréal 410, P.Q.






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Copyright © 1970 by the Canadian Anesthesiologists' Society.