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Canadian Journal of Anesthesia, Vol 17, 70-77, Copyright © 1970 by Canadian Anesthesiologists' Society

Halothane-Diethyyl Ether Ratios During Halothane-Diethyl Ether Azeotrope Anaesthesia

F. W. CERVENKO M.D.1 and S. L. VANDEWATER M.D.1

1 Department of Anaesthesiology, Queen's University at Kingston

The bond(s) which join halothane-diethyl ether azeotrope can be broken by gas chromatography, soda lime, water, and blood, in vitro and in the body. Soda lime breaks the bonding probably in a manner similar to that in gas chromatography. It is postulated that water, blood, and the body break the bonding by extractive distillation. Halothane-diethyl ether ratios in expired breath during azeotrope anaesthesia increased, indicating a greater proportional uptake of diethyl ether by the body; and the ratio tended to decrease during recovery, indicating a greater proportional elimination of diethyl ether. During recovery from azeotrope anaesthesia, expired diethyl ether concentrations were below the minimum flammability limit even without taking into consideration reformation of azeotrope in expired breath, which in itself would decrease the likelihood of flammability. Arterial and venous blood concentrations of halothane and diethyl ether during light azeotrope anaesthesia were determined. The diethyl ether blood concentrations are well below those reported for diethyl ether analgesia.






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Copyright © 1970 by the Canadian Anesthesiologists' Society.