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Canadian Journal of Anesthesia, Vol 17, 107-111, Copyright © 1970 by Canadian Anesthesiologists' Society

Protection Against Methyprylon Overdosage by Catatoxic Steroids

HANS SELYE C.C., M.D., PH.D., D.SC., F.R.S.C.1

1 Institut de Médecine et de Chirurgie expérimentales, Université de Montréal

In the rat, deep anaesthesia produced by heavy overdosage with methyprylon can be overcome both by typical catatoxic steroids (ethylestrenol, sc-11927, spironolactone, norbolethone, oxandrolone) and by glucocorticoids (prednisolone, triamcinolone). On the other hand, desoxycorticosterone, progesterone, and hydroxydione, which are devoid of glucocorticoid activity and possess little or no catatoxic potency, fail to offer significant protection against methyprylon.






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Copyright © 1970 by the Canadian Anesthesiologists' Society.