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Canadian Journal of Anesthesia, Vol 17, 112-118, Copyright © 1970 by Canadian Anesthesiologists' Society

Experimental Studies of the Central Nervous System Related to Anaesthesia: IV. Effects of Pentobarbital Placement in Caudate Nucleus

K. M. LEIGHTON M.B., F.R.C.P.(C)1 and LEONARD C. JENKINS B.A., M.D., CM., F.R.C.P.(C)1

1 Departments of Pharmacology and Surgery (Division of Anaesthesiology), University of British Columbia, Vancouver

Deep sedation results, in cats, when pentobarbital is placed in the head of caudate nucleus through precise stereotaxically implanted recording cannulae. This sedation persists in the presence of a variety of auditory stimuli, as observed by a lack of behavioural arousal and alertness and the persistence of an EEG and subcortical correlate of deactivation.

Following the application of pentobarbital into amygdala, hippocampus, ventropostero-lateral thalamic nucleus, centro-median thalamic nucleus, and posterior hypothalamic nuclei, there was no persistent behavioural or electroencephalo-graphic evidence of sedation in the presence of repetitive stimuli.






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Copyright © 1970 by the Canadian Anesthesiologists' Society.