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Canadian Journal of Anesthesia, Vol 17, 145-156, Copyright © 1970 by Canadian Anesthesiologists' Society

Nephrotoxicite Associee Au Methoxyflurane

ANDRÉ LAPOINTE M.D., F.R.C.P.(C)1 and NATALIS BELE-BINDA M.D.2

1 Anesthésiologiste, Assistant dans le Service d'anesthésie et de réanimation de l'Hêtel-Dieu de Québec
2 Anesthésiologiste, Résident étranger en anesthésie et réanimation à I'Hôtel-Dieu de Québec, Boursier de I'O.M.S.

The present study, after a brief review of the literature, points out the small incidence of nephrotoxidty associated with methoxyflurane (Penthrane) seen at I'Hôtel-Dieu de Québec. Of 17,335 anaesthetics with methoxyflurane lasting more than one hour we have observed only five cases of renal toxicity, representing an incidence of less than 0.03 per cent.

This study has permitted us to place in focus the importance of the factor of duration of anaesthesia, the possible predisposition in the diabetic and the obese, and the absence of the syndrome in obstetrical anaesthesia and infants.






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Copyright © 1970 by the Canadian Anesthesiologists' Society.