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Canadian Journal of Anesthesia, Vol 17, 157-165, Copyright © 1970 by Canadian Anesthesiologists' Society

A Double-Blind Study of Diazepam, Droperidol, and Meperidine as Premedication in Children

PATRICK M. F. McGARRY M.B., F.F.A.R.C.S.I.1

1 Assistant Professor, Faculty of Anaesthesia, University of Manitoba; Department of Anaesthesia, Grace General Hospital, Winnipeg

A double-blind study is described, using diazepam, droperidol, and meperidine for premedicatLon in children. The evaluation indicated that diazepam was the better drug.

Even though droperidol appears to be a very strong sedative, the children in this group were not as well prepared for surgery. However, since droperidol appears to have strong antiemetic properties, it can be concluded that it also can be useful as premedication to anaesthesia in children.

Although most children in the meperidine group appeared to be well prepared for surgery, with little or no sedation, we would consider this drug a poor premedication because of a high incidence of postoperative vomiting.

Diazepam had the added advantage in that postoperative emotional disturbances were less frequent than with meperidine. None of the active drugs used decreased the incidence of postoperative analgesic requirement.






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Copyright © 1970 by the Canadian Anesthesiologists' Society.