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Canadian Journal of Anesthesia, Vol 17, 331-340, Copyright © 1970 by Canadian Anesthesiologists' Society

Methoxyflurane et Nephrotoxicite: Etude de la Fonction Renale de 22 Malades Anesthesies au Methoxyflurane

GÉRARD MIGNAULT M.D.,1, BENOÎT LABRECQUE M.D., F.R.C.P.(C)1, and ET SUZANNE HAME 1

1 Les docteurs Mignault et Labrecque sont membres du Service d'anesthesie de I'Hotel-Dieu de Montréal. Mile Hamel est stagiaire d'été, étudiante en médecine a I'Université de Montréal

Renal investigation was done on 22 patients anaesthetized with methoxyflurane. One patient developed marked diuresis, persistent low osmolality, and a lessened urinary concentrating power in response to vasopressin.

Some etiological factors along with a possible physiopathological mechanism have been briefly discussed

The high incidence of this polyuric syndrome calls for a close observation of the urine output of all patients subjected to methoxyflurane anaesthesia. This agent would appear contraindicated in patients with reduced renal function.

Note:

Travail présente à la session d'automne de la Société canadienne des anesthésistes, division du Quebec






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Copyright © 1970 by the Canadian Anesthesiologists' Society.