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Canadian Journal of Anesthesia, Vol 17, 411-416, Copyright © 1970 by Canadian Anesthesiologists' Society

Clinical Trial of Ketamine (Ci-581): A Preliminary Report

S. A. ODUNTAN M.B., B.S., F.F.A.R.C.S.I., D.A.(ENG.)1 and R. Y. GOOL M.B., CH.B., D.A.(ENG.)1

1 Department of Anaesthesia, University College Hospital, Ibadan, Nigeria

Ketamine (ci-581) is a derivative of phencyclidine. It produces analgesia and anaesthesia very rapidly, has a short duration of action, and is rapidly metabolized in the body. For this reason it has been used for continuous intravenous infusion or intermittent intravenous injections. It increases blood pressure and heart rate slightly. Respiration has not been found to be depressed during its use.

A report of the use of Ketamine in 100 consecutive patients is presented. Many of these patients were considered poor risks, and it is felt that Ketamine provided a greater margin of safety than conventional anaesthesia would have done. The dose used for induction was 1-1.25 mg/kg, while the maintenance dose was 1.5-2 mg/kg/hour.






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Copyright © 1970 by the Canadian Anesthesiologists' Society.