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Canadian Journal of Anesthesia, Vol 19, 66-74, Copyright © 1972 by Canadian Anesthesiologists' Society

The Interaction Between d-Tubocurarine and Gallamine During Halothane Anaesthesia

M. M. GHONEIM M.B., B.CH., F.F.A.R.C.S.1, R. B. URGENA M.D.1, KENNETH DRETCHEN M.S.2, and J. P. LONG PH.D.2

1 Department of Anaesthesia, College of Medicine, University of Iowa, Lowa City, Iowa 52240
2 Department of Pharmocology, College of Medicine, University of Iowa, Iowa City, Iowa 52240

D-Tubocurarine, gallamine and a mixture of both drugs were each given to three separate groups of patients under halothane anaesthesia, to examine the interaction between the two non-depolarizing myoneural blocking agents. Mixing the two drugs resulted in synergism rather than simple addition. this affected the magnitude of blockade without altering its duration. Measurements in dogs ruled out the possibility that vaiation in muscle blood flow could be responsible for this synergism. That leaves the myoneural junction as the probable site of interaction.

Note:

Supported in part by the Department of Anaesthesia Trust Fund and by USPHS grants Nos. NS1.396, NS4431 and USPHS training grant 5 TO1 GM00141-11






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Copyright © 1972 by the Canadian Anesthesiologists' Society.