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Canadian Journal of Anesthesia, Vol 19, 251-262, Copyright © 1972 by Canadian Anesthesiologists' Society

D-Tubocurarine Dosage based on Lean Body Mass

NORMAN L. WULFSOHN M.B., B.CH.(RAND), F.F.A.(S.A.)1

1 Department of Anesthesiology, University of Texas Medical School at San Antonio, San Antonio, Texas

The dosage of D-tubocurarine recommended varies greatly with different authors. The body build, reflected in the lean body mass (LBM), influences the dose. The dose which produces a 90-95 per cent depression of neuromuscular blockade is better correlated to the lean body mass than the body weight.

Age and body somatotype influence this dosage.

Less D-tubocurarine is required when halothane is the anaesthetic, than when methoxyflurane or meperidine are used.

The average recovery time to 50 per cent musule power when 0.38 mg/Kg LBM is given with methoxyflurane is 38.8 minutes and this was best related to percentage fat.

Note:

Supported by NIH Grant #1 SOI FR 05654-01






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Copyright © 1972 by the Canadian Anesthesiologists' Society.