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Canadian Journal of Anesthesia, Vol 19, 263-269, Copyright © 1972 by Canadian Anesthesiologists' Society

Effects of Volatile Anaesthetic Agents on EEG Activity Recorded in Limbic and Sensory Systems

R. M. JULIEN PH.D1, EVA M. KAVAN M.D.1, and H. W. ELLIOTT M.D. PH.D1

1 Department of Medical Pharmacology & Therapeutics, University of California, Irvine, California 92664

As part of a systematic study of the effects of anaesthetic agents on cortical and subcortial actvity of experimental animals, diethyl ether, halothane, methoxyflurane, and enflurane (Ethrane) were administered to cats with chronically-implanted electrodes sterotaxically placed in selected nuclei of the sensory system (centrum medianum, ventrails posterior lateralus, and mesencephalic reticular formation) and in representative areas of the limbic system (pes hipoccampi and nucleus amygdalae). Skull electrodes were placed over frontal, parietal and/or temporal cortex.

Following induction, an anaesthetic state was maintained for at least 30 minutes and deeper levels of anaesthesia were avoided. Minimal electrographic changes were observed with ether. Spiking, particularly on the limbic system, was observed with the 3 halogenated compounds. These changes were most pronounced with enflurane.






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Copyright © 1972 by the Canadian Anesthesiologists' Society.